Enterohemorrhagic Escherichia coli Infections
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چکیده
Enterohemorrhagic Escherichia coli (EHEC) is a subset of pathogenic E. coli that can cause diarrhea or hemorrhagic colitis in humans. Hemorrhagic colitis occasionally progresses to hemolytic uremic syndrome (HUS), an important cause of acute renal failure in children and morbidity and mortality in adults. In the elderly, the case fatality rate for HUS can be as high as 50%. E. coli O157:H7 (EHEC O157:H7) has been recognized as a cause of this syndrome since the 1980s. The reservoirs for EHEC O157:H7 are ruminants, particularly cattle and sheep, which are infected asymptomatically and shed the organism in feces. Other animals such as rabbits and pigs can also carry this organism. Humans acquire EHEC O157:H7 by direct contact with animal carriers, their feces, and contaminated soil or water, or via the ingestion of underdone ground beef, other animal products, and contaminated vegetables and fruit. The infectious dose is very low, which increases the risk of disease. Infections with EHEC in other serogroups, including members of O26, O91, O103, O104, O111, O113, O117, O118, O121, O128 and O145, are increasingly recognized as causes of hemorrhagic colitis and HUS. Some of these organisms may be as significant in human disease as EHEC O157:H7; however, they are not recognized on the media used to isolate this organism, and many laboratories do not routinely screen for other strains. Although many EHEC seem to be carried asymptomatically in animals, members of some non-O157 serogroups may cause enteric disease in young animals. In rabbits, EHEC O153 has been linked to a disease that resembles HUS.
منابع مشابه
Draft Genome Sequence of Enterohemorrhagic Escherichia coli O157:H7 Strain MC2 Isolated from Cattle in France
Enterohemorrhagic Escherichia coli (EHEC) with serotype O157:H7 is a major foodborne pathogen. Here, we report the draft genome sequence of EHEC O157:H7 strain MC2 isolated from cattle in France. The assembly contains 5,400,376 bp that encoded 5,914 predicted genes (5,805 protein-encoding genes and 109 RNA genes).
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Here, we present the genome sequence of the Escherichia coli bacteriophage UFV-AREG1. This phage was isolated from cowshed wastewater and showed specificity for enterohemorrhagic E. coli O157:H7 (ATCC 43895), E. coli 0111 (CDC O11ab) and E. coli (ATCC 23229).
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متن کاملDraft Genome Sequence of Enterohemorrhagic Escherichia coli O157 NCCP15739, Isolated in the Republic of Korea
Enterohemorrhagic Escherichia coli (EHEC) is the main cause of the recent outbreaks of diarrhea, hemolytic-uremic syndrome (HUS), and hemorrhagic colitis worldwide. Herein, we present the draft genome sequence of the NCCP15739 isolate from a patient in the Republic of Korea.
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Multilocus sequence typing of 169 non-O157 enterohemorrhagic Escherichia coli (EHEC) isolated from patients with hemolytic uremic syndrome (HUS) demonstrated 29 different sequence types (STs); 78.1% of these strains clustered in 5 STs. From all STs and serotypes identified, we established a reference panel of EHEC associated with HUS (HUSEC collection).
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